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Table 5 Overall survival and progression-free survival dating from enrollment and, separately, first injection: median and six-month intervals (data cut off 31 Dec 21)

From: Phase 2 study of AV-GBM-1 (a tumor-initiating cell targeted dendritic cell vaccine) in newly diagnosed Glioblastoma patients: safety and efficacy assessment

 

From enrollment

From first injection

OS

PFS

OS

PFS

N (censored)

60 (21)

60 (10)

57 (19)

57 (9)

Median (months)

16.0

10.4

14.0

8.5

95% CI on Median

12.9:20.6

8.6:11.7

10.1:18.3

6.5:9.1

Percent Surviving*

(remaining at risk at the indicated time)

6 months

89.5%(51)

77.7%(45)

87.5%(49)

69.7%(39)

12 months

70.2%(40)

34.5%(20)

55.4%(31)

26.8%(15)

18 months

44.5%(20)

20.2%(9)

38.5%(16)

16.1%(6)

24 months

26.8%(9)

12.6%(5)

25.2%(7)

10.0%(3)

  1. *If no date of progression, observation for progression ends on last date known alive
  2. All n = 39 deceased are considered progressed
  3. If no event at the indicated time, then percent surviving is as of the most recent event before the indicated time