Fig. 1

A Patient history showing major therapeutic interventions and time points of PDX establishment. B Histological analyses of R1, R2, PDX_R1 and PDX_R2 after hematoxylin/eosin and Ki67 staining. C Venn diagram showing the common and specific mutations between onset, R1 and R2. D Venn diagram showing the common and specific mutations between R1 and PDX_R1. E Venn diagram showing the common and specific mutations between R2 and PDX_R2. F Venn diagram showing the common and specific mutations between PDX_R1 and PDX_R2