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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Cellular senescence in cancer: clinical detection and prognostic implications

Fig. 1

Overview of approaches of ex and in vivo detection of cellular senescence with corresponding senescence markers in cancer patients. IHC, immunohistochemistry; SA-β-Gal, senescence-associated beta-galactosidase; FFPE, formalin-fixed paraffin-embedded; SAHF, senescence-associated heterochromatin foci; γH2AX, phosphorylated H2AX; FCM, flow-cytometry; HGMB1, high mobility group box 1; RT-PCR; reverse transcription–polymerase chain reaction; MS, mass spectrometry; SASP, senescence-associated secretory phenotype; EVs, extracellular vesicles; NGS, next-generation sequencing; ddPCR, digital droplet polymerase chain reaction; cfDNA, cell-free DNA; PET-imaging, positron emission tomography-imaging

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