Table 3 Number of irAEs grouped by 18 tissue or organ disorders in different patient sex groups
From: Patterns of toxicity burden for FDA-approved immune checkpoint inhibitors in the United States
| Â | Cemiplimab Number/ratio | Nivolumab Number/ratio | Pembrolizumab Number/ratio | Atezolizumab Number/ratio | Avelumab Number/ratio | Durvalumab Number/ratio | Ipilimumab Number/ratio | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Male | Female | Male | Female | Male | Female | Male | Female | Male | Female | Male | Female | Male | Female | |
BL | 0/0.00 | 10/0.20 | 1,485/0.34 | 2,468/0.57 | 1,093/0.27 | 1,681/0.57 | 902/0.44 | 979/0.47 | 53/0.33 | 92/0.56 | 157/0.26 | 385/0.64 | 673/0.37 | 993/0.55 |
CD | 1/0.03 | 2/0.06 | 1,111/0.28 | 2,497/0.63 | 695/0.33 | 1,283/0.61 | 344/0.32 | 599/0.56 | 41/0.27 | 82/0.54 | 132/0.30 | 243/0.56 | 479/0.29 | 1,035/0.62 |
ELD | 0/0.00 | 0/0.00 | 149/0.39 | 222/0.58 | 89/0.50 | 77/0.44 | 47/0.51 | 44/0.47 | 1/0.14 | 5/0.71 | 15/0.52 | 11/0.38 | 67/0.34 | 122/0.62 |
EnD | 0/0.00 | 0/0.00 | 1,458/0.34 | 2,513/0.58 | 856/0.38 | 1,132/0.51 | 327/0.39 | 366/0.43 | 32/0.26 | 56/0.45 | 80/0.28 | 140/0.48 | 1,071/0.34 | 1,715/0.55 |
ED | 0/0.00 | 2/0.25 | 620/0.37 | 912/0.58 | 421/0.46 | 446/0.49 | 94/0.35 | 136/0.51 | 6/0.22 | 15/0.56 | 46/0.43 | 46/0.43 | 321/0.35 | 511/0.56 |
GD | 0/0.00 | 9/0.15 | 3,849/0.34 | 6,497/0.55 | 2,834/0.44 | 3,267/0.50 | 1,235/0.40 | 1,522/0.49 | 107/0.30 | 203/0.57 | 345/0.37 | 501/0.53 | 2,555/0.34 | 4,201/0.56 |
HD | 2/0.4 | 11/0.22 | 1,539/0.33 | 2,686/0.58 | 1,092/0.36 | 1,696/0.56 | 494/0.35 | 727/0.52 | 33/0.25 | 75/0.56 | 164/0.35 | 234/0.51 | 881/0.34 | 1,491/0.57 |
ID | 4/0.12 | 6/0.18 | 420/0.27 | 704/0.58 | 403/0.36 | 596/0.52 | 172/0.47 | 145/0.40 | 21/0.35 | 29/0.48 | 30/0.36 | 39/0.46 | 214/0.29 | 346/0.47 |
MnD | 3/0.08 | 3/0.08 | 1,994/0.33 | 3,737/0.46 | 1,183/0.39 | 1,639/0.54 | 600/0.40 | 746/0.50 | 72/0.42 | 87/0.50 | 114/0.33 | 192/0.56 | 1,096/0.34 | 1,924/0.61 |
McD | 3/0.10 | 3/0.10 | 1,863/0.34 | 3,252/0.61 | 1,410/0.43 | 1,634/0.50 | 411/0.40 | 494/0.48 | 40/0.28 | 74/0.51 | 163/0.39 | 202/0.48 | 741/0.33 | 1,304/0.58 |
NMU | 1/0.03 | 7/0.19 | 3,225/0.32 | 6,146/0.59 | 2,466/0.36 | 3,816/0.56 | 424/0.38 | 593/0.53 | 48/0.31 | 91/0.59 | 281/0.28 | 582/0.58 | 1,338/0.33 | 2,293/0.57 |
NsD | 3/0.04 | 12/0.17 | 2,439/0.34 | 4,238/0.61 | 1,797/0.42 | 2,215/0.52 | 847/0.43 | 941/0.47 | 58/0.24 | 148/0.61 | 225/0.36 | 332/0.53 | 1,145/0.33 | 2,089/0.60 |
PD | 2/0.13 | 3/0.19 | 635/0.35 | 1,132/0.59 | 506/0.45 | 584/0.51 | 160/0.42 | 198/0.52 | 13/0.29 | 28/0.62 | 70/0.47 | 65/0.44 | 321/0.37 | 513/0.59 |
RuD | 0/0.00 | 8/0.26 | 1,023/0.27 | 2,494/0.62 | 990/0.37 | 1,525/0.57 | 391/0.31 | 739/0.59 | 28/0.17 | 97/0.60 | 120/0.46 | 108/0.42 | 504/0.28 | 1,150/0.65 |
RB | 0/0.00 | 0/0.00 | 97/0.37 | 152/0.65 | 106/0.52 | 87/0.42 | 57/0.60 | 34/0.36 | 3/0.50 | 3/0.50 | 6/0.30 | 12/0.60 | 49/0.47 | 52/0.50 |
RTM | 5/0.07 | 10/0.14 | 2,782/0.30 | 5,763/0.59 | 1,900/0.33 | 3,454/0.60 | 901/0.37 | 1,225/0.50 | 69/0.64 | 178/0.64 | 416/0.27 | 934/0.61 | 1,059/0.32 | 2,051/0.61 |
SSD | 3/0.08 | 5/0.13 | 2,244/0.34 | 3,842/0.58 | 1,831/0.41 | 2,214/0.50 | 537/0.39 | 593/0.44 | 40/0.52 | 88/0.52 | 177/0.40 | 196/0.45 | 1,189/0.34 | 1,979/0.57 |
VD | 2/0.07 | 6/0.21 | 885/0.35 | 1,522/0.60 | 815/0.47 | 802/0.46 | 355/0.39 | 459/0.50 | 35/0.26 | 86/0.64 | 112/0.40 | 144/0.51 | 444/0.37 | 673/0.57 |