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Fig. 10 | Journal of Experimental & Clinical Cancer Research

Fig. 10

From: STRIP2 motivates non-small cell lung cancer progression by modulating the TMBIM6 stability through IGF2BP3 dependent

Fig. 10

STRIP2 cooperates with IGF2BP3 to promote NSCLC progression dependent on TMBIM6. a The efficiency of si-TMBIM6 was analyzed using western blotting and quantitative RT-PCR in PC9 cells. b Cell proliferation was detected using CCK-8 after TMBIM6 knockdown in PC9 cells. c Cell migratory and invasive abilities were measured by Transwell assay. d Cell viability was performed using CCK-8 and statistically analyzed in IGF2BP3 or STRIP2 overexpression PC9 cells with TMBIM6 knockdown. e Cell migratory and invasive abilities were measured using Transwell assay. f Immunohistochemistry staining of STRIP2, IGF2BP3 and TMBIM6 in a NSCLC tissue microarray containing 48 paired normal and NSCLC tissues. Scale bar, 100 μm. g The percent of samples showing low or high STRIP2 expression relative to the levels of IGF2BP3 and TMBIM6 are shown. h Kaplan-Meier analysis of overall survival and disease-free survival data from TCGA NSCLC datasets containing 601 patients. Data represent mean ± SEM from three independent experiments. *, p < 0.05; **, p < 0.01; ***, p < 0.001 were determined by one-way ANOVA with Tukey’s post hoc analysis. OE, overexpression

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