Fig. 5

Knockdown of STRIP2 suppresses tumor growth and metastasis in vivo. a Effects of A549 knockdown cells on tumor growth in subcutaneously implanted BALB/c mice (n = 9). b Endpoint tumor size and mass in BALB/c mice (n = 9). c Effects of A549 knockdown cells on body weight in BALB/c mice. d STRIP2 and Ki-67 expressions were detected using western blotting. e Representative images showing luciferase expression from lung metastasis of both A549 control and shSTRIP2 group. f HE staining of lungs from both control and shSTRIP2 groups resected from tail vein injection metastasis mouse model. *, p < 0.05; **, p < 0.01; ***, p < 0.001 were determined by one-way ANOVA with Tukey’s post hoc analysis