Fig. 7

STRIP2 promotes tumor progression dependent on IGF2BP3 in NSCLC. a IGF2BP3 level was detected using western blotting and statistically analyzed in IGF2BP3 knockdown PC9 cells with STRIP2 overexpression. b Cell viability was measured using CCK-8 assay. c Cell migratory and invasive abilities were detected using Transwell assay. d RT-qPCR analysis of IGF2BP3 mRNA level in 51 paired NSCLC and normal tissues. e IGF2BP3 mRNA expression was investigated in GSE32863 database and compared between normal (n = 58) and NSCLC (n = 58) tissues. f Correlation analysis between STRIP2 expression and IGF2BP3 level. g IGF2BP3 mRNA and protein levels were detected using quantitative RT-PCR and western blotting in STRIP2 overexpression. Data represent mean ± SEM from three independent experiments. *, p < 0.05; **, p < 0.01; ***, p < 0.001 were determined by one-way ANOVA with Tukey’s post hoc analysis. OE, overexpression