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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: STRIP2 motivates non-small cell lung cancer progression by modulating the TMBIM6 stability through IGF2BP3 dependent

Fig. 8

STRIP2 cooperates with IGF2BP3 to stabilize TMBIM6 mRNA. a Heat map shows differential gene expression between shCtrl and shSTRIP2 samples. b The top 20 enriched GO terms for differentially expressed genes (DEGs). c Venn diagram showing the 16 overlapping genes of STRIP2 knockdown RNA-sequence data and IGF2BP3 RIP-sequence and GEO database (GSE90684). d RT-qPCR analysis of 8 overlapping genes and MYC transcript levels in the STRIP2 knockdown and IGF2BP3 knockdown A549 cells. e-f The half-life of TMBIM6 after treatment with 5 μg/ml actinomycin D for the indicated times in the IGF2BP3 knockdown PC9 cells with STRIP2 overexpression. Data represent Mean ± SEM from three independent experiments. *, p < 0.05; ***, p < 0.001 were determined by one-way ANOVA with Tukey’s post hoc analysis. OE, overexpression

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