Fig. 3
From: PCSK9 facilitates melanoma pathogenesis via a network regulating tumor immunity
GSEA (gene set enrichment analysis) analyses on tumors produced by B16 EV, PCSK9, D374Y, and Q152H cells. (a-c) RNA-seq was performed on 3 tumors for each xenograft type. GSEA was carried out on MSigDB hallmark gene sets collection for the indicated comparison using Galaxy. Enriched gene sets with p < 0.05 are graphed according to normalized enrichment scores. The unique gene sets enriched are marked with red. (d-f) Top enriched gene set profiles for the indicated comparison. NES: normalized enrichment score. LEG: leading edge genes