Fig. 1

A Probability of 5 year event free survival (EFS) [%] and (B) corresponding cumulative incidence of relapse (CIR) according to the maximum total bilirubin toxicity during induction/consolidation – protocols IA/IB –in the in the AIEOP ALL-BFM 2000 study population with available bilirubin information (n = 1547 patients). Bilirubin toxicity grading was according to the Common Toxicity Criteria (CTC) of the National Cancer Institute, version 2; standard error (SE) and the number of included individuals are indicated for each category