Fig. 2

Frequency of rs6744284 genotype by bilirubin toxicity grading in induction/consolidation (protocols IA/IB) treatment according to the Common Toxicity Criteria of the National Cancer Institute, version 2 (CTC) (A), and by UGT1A1*28/*37 genotype (B). The number of patients (n) for each rs6744284 genotype is given above the columns. A analysis based on 650 patients of the discovery cohort; (B) based on a subset of 544 patients subsequently genotyped for UGT1A1*28/*37 depending on availability of DNA