Fig. 4From: Chemotherapy-related hyperbilirubinemia in pediatric acute lymphoblastic leukemia: a genome-wide association study from the AIEOP-BFM ALL study groupCumulative incidence of relapse (CIR) at 5 years in ALL patients from the discovery cohort according to (A) maximum total bilirubin toxicity grade during induction/consolidation (protocols IA/IB); (B) rs6744284 genotype (CC, TC, TT); and (C) homozygosity for the UGT1A1*28 or *37 allele. D shows the effect of the rs6744284 genotype (CC/TC and TT) on CIR in the group of patients with high bilirubin levels (n = 68; grades 3 and 4). Bilirubin toxicity grading was according to the Common Toxicity Criteria (CTC) of the National Cancer Institute, version 2; standard error (SE) and the number of included individuals are indicated for each categoryBack to article page