Fig. 6

Targeting BCAR4 inhibits tumor growth and metastasis in vivo. A The image of xenografts isolated from immunodeficient mice one month after the treatment. B Growth curve of xenografts treated with the in vivo BCAR4 siRNA or a control. Mean ± SD was shown. * P < 0.05, **P < 0.01. C and D The image and HE staining of mouse lungs and livers. The incidence of lung and liver metastasis in mice with the BCAR4 siRNA was shown in the table. E Representative images of immunohistochemical analysis of CCR7, E-cadherin, VEGF and Vimentin in xenografted tumors. Blue indicated nuclear staining and brown indicated the target protein in IHC