Fig. 1
S1P/SPHK signaling in human lymphomas and PFS and OS in overweight lymphoma patients. A IHC staining of S1P was performed in the tissue array-samples from various human lymphomas and computer-imaging analysis indicated the S1P expression levels of three subtypes lymphomas, DLBCL, FL and PTCL, in comparison with the normal lymph node samples. B By using Gene Expression Omnibus (GEO) database, SPHK1 expression and SPHK2 expression were analyzed in DLBCL, FL and PTCL patients. C A cohort of 2094 lymphoma patients was recruited and PFS and OS in two groups (BMI ≥ 25 kg/m2 and BMI < 25 kg/m2) were analyzed in DLBCL, FL and PTCL-NOS patients. PFS: progression-free survival; OS; overall survival; DLBCL: Diffuse large B-cell lymphoma; FL: follicular lymphoma; PTCL: peripheral T-cell lymphoma; PTCL-NOS: peripheral T-cell lymphoma-not otherwise specified; CLL/SLL: Chronic lymphocytic leukemia/Small lymphocytic lymphoma; HL: Hodgkin’s Lymphoma; MZL: Marginal zone lymphoma; MCL: Mantle cell lymphoma; CTCL: Cutaneous T-cell lymphoma. *, P < 0.05; **, P < 0.01