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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Repurposing nitric oxide donating drugs in cancer therapy through immune modulation

Fig. 5

Low-dose SNAP treatment induces alterations in macrophage subsets. (A) Subclustering of tumor-associated macrophages (TAMs) by UMAP and identifying the top three DEGs in each subset of TAMs. The top three DEGs were identified using the “FindAllMarker” function in the Seurat package. (B) The distribution of each TAM defined by gene expression patterns in the control or low-dose SNAP treatment groups. (C) The expression levels of M1-related and M2-related genes in the TAM subset. (D) Ridge plots determining the expression distributions of M1-related genes (Cxcl3) and M2-related genes (Arg1) in the TAM subsets. The X-axis represents log-normalized expression levels

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