Fig. 3

PDOs response to drug screening. (A) Log transformed dose–response curves in selected standard drugs and non-standard (C) drugs. (B) Z-score Ln-AUCs heatmap (red: no response; blue: good response) for standard treatment. (D) Z-score Ln-AUCs heatmap (red: no response; blue: good response) for non-standard treatment (lower panel), matched with genomic data. In the upper panel are depicted main gene mutations, in the following loss of heterozygosity (LOH) and in the last copy number variations