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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: “Proteotranscriptomic analysis of advanced colorectal cancer patient derived organoids for drug sensitivity prediction”

Fig. 5

Proteotranscriptomic characterization of oxaliplatin responder lines in comparison with no-responder ones. (A) Network mapping of 95 proteins showing the 4 sub-clusters composed of more than 3 proteins. Relevant proteins with no associations to others are represented as isolated nodes. Colors are depicted according to the protein abundance (log2ratio) compared to responder PDOs (left panel). Bar-chart of GO terms represented as percentage of annotated proteins using the same color coding (right panel). (B) Hierarchical clustering heatmap of differentially expressed genes per transcriptomic. (C) GSEA hallmarks analysis of RNA-seq data. NES: normalized enrichment score. FDR: false discovery rate. R: responder; NR: non responder

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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