Fig. 8

Integrative functional network analysis of palbociclib RNA/protein fused dataset. Highest confidence interactions (score 0.9) showing modules. Nodes in red correspond to proteins identified as differentially expressed by RNA-seq only, in blue those identified by proteomics only and in green those identified by both omics. Grey line marks on the left 7 metabolism related modules with the highest integration. Key for metabolic modules: 1: Oxidative phosphorylation; 2: Pentose phosphate pathway, and Glycolysis; 3: Metabolism of nucleotides, and purinergic nucleotide receptor signaling pathway; 4: PPARA signaling pathway; 7: Lipid biosynthetic process; 9: Oxidoreductase activity; 10: Organonitrogen compound metabolic process. Key for modules on the right: 1: Regulation of signal transduction; 2: Regulation of cell communication and motility; 3: Translation; 4: RNA splicing; 5: Transcription and DNA repair; 6: Cell cycle; 7: Membrane trafficking; 8: Proteasome; 9: Protein ubiquitination; 10: Interferon signaling; 11: ER-Golgi vesicle-mediated transport; 12: TRiC/CCT complex. Details of the modules are indicated in Additional file 2