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Table 1 Allelic fraction (AF) distribution in PDOs and matched tissues of main driver, hotspot and not hotspot mutations with potential relevance. Each mutation has been manually reviewed in Integrative Genome Viewer (IGV). Only mutations with an AF of at least 5% in PDOs have been included

From: “Proteotranscriptomic analysis of advanced colorectal cancer patient derived organoids for drug sensitivity prediction”

Patient

Gene

Mutation

PDOs VAF

Tissue VAF

mCTO8

BRAF

p.D594G

0.5118

0.3675

mCTO19

TP53

KRAS

APC

p.R273C

p.G12S

p.E1309Dfs*4

0.4319

0.3282

0.1862

0.3766

0.356

0.1247

mCTO21

KRAS

MYC

p.G12D

p.T73P

0.4274

0.0975

0.2

-

mCTO24S2

PIK3CA

KRAS

APC

p.H1047R

p.G12D

p.Y935*

0.5056

0.5089

1

0.1642

0.1682

0.285

mCTO24S7

PIK3CA

KRAS

APC

MYC

CDKN2A

p.H1047R

p.G12D

p.Y935*

p.T73P

p.D74A

0.4852

0.4978

0.9965

0.0975

0.0898

0.1529

0.1935

0.3412

-

-

mCTO38S5

TP53

APC

FBXW7

p.R248W

p.Q1367*

p.R222*

0.9967

0.994

0.6828

0.5272

0.4723

0.2438

mCTO38S8

TP53

APC

FBXW7

p.R248W

p.Q1367*

p.R222*

0.9966

0.9933

0.5113

0.2991

0.3066

0.1531

mCTO43

TP53

APC

p.Y236H

p.Y935*

0.9975

0.9804

0.3309

0.2581

mCTO46

ERBB3

PIK3CA

KRAS

TP53

p.T355I

p.K111E

p.G12S

p.R273H

0.6528

0.5521

0.99

0.99

0.502

0.3632

0.4512

0.5022

mCTO47

TP53

MYC

GNAS

APC

EGFR

p.R213*

p.T73P

p.R201S

p.E1379Vfs*7

p.L833Gfs*63

0.9983

0.1158

-

-

-

-

-

0.0606

0.156

0.0895

mCTO50

TP53

PTEN

PIK3R1

p.G245S

p.K267Rfs*9

p.R348*

0.4752

0.9504

0.4696

na

mCTO50B

TP53

PTEN

PIK3R1

p.G245S

p.L257V

p.K267Rfs*9

p.R348*

0.4893

0.1695

0.9511

0.4993

0.2895

0.0848

0.3198

0.1592

mCTO66S3

TP53

KRAS

APC

p.M237I

p.G12V

p.E1379*

0.988

0.4407

0.998

0.8701

0.4611

0.9554

RTO2

PIK3CA

KRAS

FBXW7

p.E545K

p.G12V

p.S582P

0.464

0.5106

0.4626

0.2827

0.3149

0.2964

RTO7

TP53

APC

SMAD4

p.C275Y

p.Y935*

p.P356S

1

0.4842

1

0.2904

0.1005

0.1742

  1. VAF Variant allele frequency