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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: MiR-455-5p suppresses PDZK1IP1 to promote the motility of oral squamous cell carcinoma and accelerate clinical cancer invasion by regulating partial epithelial-to-mesenchymal transition

Fig. 1

MiR-455-5p promotes OSCC cell migration and invasion. A MiR-455-5p expression in patients with and without node metastasis, or with and without clinical risk factors (perineural invasion, lymphovascular invasion, or extracapsular extension) in database of NKCU-OrCA-40TN. B MiR-455 expression in patients with and without early tumor event (new tumor event within one year) after initial treatment recorded in the TCGA head and neck carcinoma data set. C MiR-455-5p expression in OEC-M1 cells transfected with pLe-miR-455-5p plasmids and with vector control. D MiR-455-5p expression in OEC-M1 cells transfected with miR-455-5p inhibitor and controls. E Migration ability (determined by wound-healing assay) of OEC-M1 cells transfected with pLe-miR-455-5p plasmids and controls. F Migration ability (determined by wound-healing assay) of OEC-M1 cells transfected with miR-455-5p inhibitor and controls. G Migration ability of SAS cells transfected with miR-455-5p mimics (and controls) H Migration and invasion ability (determined by two-chamber transwell assay) of HSC-3 cells transfected with pLe-miR-455-5p plasmids and controls. I, J XY plots indicating the position of HSC-3 cells transfected with control vectors (I) or pLe-miR-455-5p (J) tracked for 5 h. K Total distance in XY plot (I, J). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 by two-tailed Student’s t test

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