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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: MiR-455-5p suppresses PDZK1IP1 to promote the motility of oral squamous cell carcinoma and accelerate clinical cancer invasion by regulating partial epithelial-to-mesenchymal transition

Fig. 7

Schematic illustrating how OSCC migration is promoted by the miR-455-5p-PDZK1IP1 axis. Positive feedback occurs when PDZK1IP1 suppression facilitates TGF-β signaling and then induces miR-455-5p expression. MiR-455-5p upregulation and PDZK1IP1 suppression induce EMT and partial EMT, which contribute to collective migration, invasion, and poor clinical outcomes in OSCC. (ECE Extracapsular extension, LVI Lymphovascular invasion)

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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