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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Single-nucleus RNA sequencing and deep tissue proteomics reveal distinct tumour microenvironment in stage-I and II cervical cancer

Fig. 2

The MΦs of the CCI and CCII groups shows distinct levels of immune response. (A) The hierarchy diagram compares the expression and correlation of the top 50 DEGs between the CCI and CCII groups. (B) The 2D t-SNE graph compares the distribution of MΦs expressing (the normalised expression) the genes (FC > 1.2, P-value < 0.05) associated with the signalling of chemokines, cytokines and interleukins in the CCI and CCII groups. (C) The GSEA analysis of the Hallmark pathways enriched respectively by the DEGs of the CCI and CCII groups. The ranking of the genes significantly associated with the epithelial mesenchymal transition (D) and the IFN-α response pathway (E)

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