Fig. 4
T cells were less activated in the CCII group patients. (A) The comparison of the proportions of CD8+, γδT and Treg cells of entire T cell populations of the CCI and CCII groups. (B) The number of three T cell populations detected in the TME of individual patients. (C) The 2D-tSNE graphs comparatively display the distributions of different T cells, and the expression (in normalised value) of selected marker genes (incl. CD8A, CD4, PRF1, IFIT3, IFNGR1, IFNGR1, and CTLA4) in the CCI and CCII groups. (D) The hierarchical clustering of the top 100 DEGs between the three T cell types of the two groups (FC > 1.5 and P-value < 0.05)