Fig. 7

The tumour associated stem cells (TASCs) and epithelial cells were more immune response active in the TME of CCI patients. (A) The 2D-tSNE graphs show the expression density of selected marker genes of cancer stem cells (CSCs), mesenchymal stem cells (MSCs), adipose-derived stromal cells (ADSCs) and vascular stem cells (VSCs). (B) The heatmap hierarchically compares the top 10 DEGs of each stem cell-like population in the two groups. The GSEA of the top 6 biological processes enriched (P-value < 0.05) in the CSCs (C) and ADSCs (D) of CCI and CCII groups, respectively. The KEGG pathways enriched in the basal cells (E) and epithelial cells (F) of the CCI group. (G) The comparison of the average expression of keratin and collagen genes with respect to their percentage of expression in the two groups