Fig. 8

Quantitative proteomic comparison of the tumour tissues collected from the CCI (n = 3) and CCII (n = 3) patients. (A) Hierarchically clustering of DEP contents (in Z-score) identified from different patients. (B) Volcano graph displays the Log₂FC versus -Log₁₀P-value of the top 60 DEPs of the CCII relative to the CCI group. (C) The protein–protein interactions among the DEPs significantly upregulated in the CCII group. (D) The top 8 Hallmark pathways enriched in the two groups, predicted by the GSEA. (E) The expression profiles of the genes in different immune cells expressing the DEPs associated with INF-α response pathway identified in (D). (F) The correlation between the Log₂FC values of the top 20 DEPs in the CCII group relevant to immune processes (based on GO terms) and their gene expression in different immune cell populations of the two groups