Table 3 The signaling pathways identified by KEGG enrichment analysis. The RNA expression levels of cytokines and chemokines were significantly modulated by LPPC/MP, LPPC/MP/CD28, and LPPC/MP/CTLA4. Ten upregulation pathways and three downregulation pathways were enriched
| Â | ID | Description | GeneRatio | P-value |
|---|---|---|---|---|
Upregulation | hsa04060 | Cytokine-cytokine receptor interaction | 24/64 | 6.64E-19 |
hsa04062 | Chemokine signaling pathway | 13/64 | 2.06E-09 | |
hsa04657 | IL-17 signaling pathway | 11/64 | 1.17E-10 | |
hsa04620 | Toll-like receptor signaling pathway | 10/64 | 6.21E-09 | |
hsa04621 | NOD-like receptor signaling pathway | 10/64 | 1.40E-06 | |
hsa04668 | TNF signaling pathway | 9/64 | 1.83E-07 | |
hsa04630 | JAK-STAT signaling pathway | 8/64 | 3.49E-05 | |
hsa04151 | PI3K-Akt signaling pathway | 8/64 | 6.12E-03 | |
hsa04064 | NF-kappa B signaling pathway | 7/64 | 1.52E-05 | |
hsa04659 | Th17 cell differentiation | 5/64 | 1.52E-03 | |
Downregulation | hsa04064 | NF-kappa B signaling pathway | 4/11 | 7.66E-06 |
hsa04620 | Toll-like receptor signaling pathway | 4/11 | 7.66E-06 | |
hsa04010 | MAPK signaling pathway | 4/11 | 4.45E-04 |