Fig. 3

Secondary screening identifies sunitinib as a high-potency inhibitor of RB organoid growth. A–H Dose-response curves of 8 drugs tested on three organoids. I–K Data from A–H were used to calculate IC₅₀ (I), HS (J), and E_max (K) values in the three RB organoids (colored circles). Boxes and whiskers indicate median values with interquartile ranges and variability outside the upper and lower quartiles, respectively. RTKs: receptor tyrosine kinases; TOP2: topoisomerase II. L–P Dose-response curves of sunitinib compared with the indicated drugs in five RB organoid lines