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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Procoxacin bidirectionally inhibits osteoblastic and osteoclastic activity in bone and suppresses bone metastasis of prostate cancer

Fig. 2

Pro specifically inhibits cancer-induced OB activation and osteogenesis. A Cell viability of MC3T3-E1, C3H10T1/2 and mBMSCs with 48-h IC50 values indicated. B Luciferin luminescence intensity (RLI) in MC3T3-ORE cells treated with Pro at indicated concentrations. C Effect of Pro (400 nM) on mRNA level of osteoblastic marker genes in MC3T3-E1 cells cultured in basal medium or PM. D and E Alizarin Red S staining in directly cultured (D) or co-cultured (E) MC3T3-E1 cells treated with or without Pro for 21 days. (F) RLI in co-cultured MC3T3-ORE cells treated with Pro at indicated concentrations. **P < 0.01, ***P < 0.001, ns, no significance

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