Procoxacin bidirectionally inhibits osteoblastic and osteoclastic activity in bone and suppresses bone metastasis of prostate cancer

Table 2 Predicted targets of Procoxacin by virtual screening

Target	Similarity^a	PBD ID	ΔG^b
RAF/14-3-3ζ complex	0.87/0.41	4IHL	-9.4
FKBP/mTOR complex	0.83/0.35	4DRI 4DRJ 4DRH	-9.1
Protein phosphatase PP1	0.94/0.43	1JK7 1U32	-7.5
Nuclear receptor RORγ	0.86/0.35	3B0W	-6.6
Actin	0.81/0.37	2ASP	-5.7

^aDice similarity coefficient with the topological pharmacophore fingerprint and Morgan fingerprint, respectively
^bPredicted by molecular docking of Pro with targets in kcal/mol

ISSN: 1756-9966