Integrated multi-dimensional analysis highlights DHCR7 mutations involving in cholesterol biosynthesis and contributing therapy of gastric cancer

Table 1 Germline mutations identified by GWAS analysis

Chr.^a	Variant	Major/Minor Allele	Associated Gene	Case^b	Control^b	MAF^c		P_value^d	OR (95% CI)	P_value
Chr.^a	Variant	Major/Minor Allele	Associated Gene	Case^b	Control^b	Case	Control	P_value^d	OR (95% CI)	P_value
1:196989521	rs191281603	C/G	CFHR5	102/83/3	258/29/0	0.237	0.051	2.49E-12	7.501 (4.645 ~ 12.113)	7.47E-19
11:126339488	rs240541	A/G	DCPS	46/94/29	13/117/157	0.450	0.751	3.00E-11	0.546 (0.228 ~ 1.312)	1.74E-01
11:71444111	rs104886038	A/G	DHCR7	169/22/0	185/99/0	0.058	0.174	5.74E-09	0.243 (0.147 ~ 0.404)	1.04E-08

^aBased on GRCh38
^bMajor homozygote/heterozygote/minor homozygote
^cMAF, minor allele frequency
^dP_value of GWAS based on the combination of the training set and validation set

ISSN: 1756-9966