Table 2 The effects of the single L68P mutation and co-mutations with L68P on DHCR7 protein stability
Co-mutation pair | Multiple Mutation ΔΔG | Single Mutation ΔΔG (L68P: -0.36 kcal/mol) |
|---|---|---|
L68P + P51S | -2.9 | -2.31 |
L68P + G244R | -0.59 | -0.86 |
L68P + A247V | 0.37 | 0.87 |
L68P + W248C | -1.91 | -2.2 |
L68P + V326L | -1.16 | -0.37 |
L68P + Y408H | -0.72 | -1.57 |
L68P + G410R | -1.59 | -0.77 |
L68P + R443C | -1.66 | -1.24 |