Fig. 1

Design overview and molecular characteristics of the ESCC microarray cohort. (A) Schematic diagram of the study design. (B) 351 differentially expressed genes with log fold change > 2 and P < 0.01 between paired peri- and tumor samples in ESCC were shown as heatmap with differential degree (D), tumor (T), nodal (N) and stages information. (C) Differences in hallmark pathway activities scored by GSVA between paired peri- and tumor samples in ESCC. Shown are t values from a linear model, corrected for patient of origin. (D) KEGG Pathway enrichment analysis result of the differentially expressed genes in ESCC