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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Integrative analysis of bulk and single-cell gene expression profiles to identify tumor-associated macrophage-derived CCL18 as a therapeutic target of esophageal squamous cell carcinoma

Fig. 4

Comparative analysis of cell communication identified differentially expressed ligand-receptor pairs in ESCC. (A) Heatmap showing the expression of ligand-receptor pairs highly expressed in ESCC TME. (B) The significantly related ligand–receptor interactions in the ESCC TME inferred by CellChat analysis. Kaplan–Meier curves of overall survival of ESCC microarray cohort stratified by the expression of CCL18 (C) and PITPNM3 (D). (E) A circle plot showing the cell–cell communication network of CCL18-PITPNM3 axis estimated by CellChat. (F) CCL18 visualization by immunofluorescence imaging in conjunction with CD68+ M1 macrophages or CD206+ M2 macrophages

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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