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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: The BRD4 inhibitor JQ1 augments the antitumor efficacy of abemaciclib in preclinical models of gastric carcinoma

Fig. 4

Molecular mechanism of the combination of ABE and JQ1 in GC cell lines revealed by RNA-seq. A Heatmap of differential expressed genes among AGS cells with different treatments and time points. HALLMARK and REACTOME functions are annotated on the right. B GSEA plots of ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS of comparisons among different treatments and timepoints. C Heatmap of cell cycle-related genes. D Dot plot of enriched pathways in different comparisons. In each comparison, pathways enriched in upregulated genes are colored in red and those enriched in downregulated genes are in blue. E Box plots showing the expression levels of marker genes of PROLIFERATION (MKI67, MCM2), DNA REPAIR (RAD51, BRCA1), CELLULAR SENESCENCE (CDKN1A, LMNB1) and SASP (CXCL8, CCL20). F Network of genes involved in five DNA repair pathways of the indicted cohort. JQ1 vs. DMSO cohort has no related downregulated DNA repair genes. Colors denote different pathways. The dot size is corresponding to fold change. Different shapes denote different treatments

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