Fig. 8
From: Water channel protein AQP1 in cytoplasm is a critical factor in breast cancer local invasion
Both in vivo assay and clinical analysis data confirmed that AQP1 induced breast cancer progression by interacting with ANXA2 and Rab1b. a-e Survival times between animal groups were compared (log-rank test). The Flag-AQP1/MDA-MB-231 (n = 20) mice group had a shorter survival time compared with Flag-vector/MDA-MB-231 (n = 14) mice group (a); Flag-AQP1/shANXA2 #1/MDA-MB-231 (n = 17) mice group (b) and Flag-AQP1/shRab1b #1/MDA-MB-231 (n = 20) mice group (c) also had a longer survival time when compared with Flag-AQP1/MDA-MB-231 (n = 20) mice group; The survival time was not changed between shANXA2 #1/MDA-MB-231 (n = 19) and Flag-AQP1/shANXA2 #1/MDA-MB-231 (n = 17) mice group (d); Comparison of survival curve between shRab1b #1/MDA-MB-231 (n = 20) and Flag-AQP1/shRab1b #1/MDA-MB-231 (n = 20) mice group (e). f, g Kaplan–Meier analysis of survival of 194 IDC patients with AQP1 high cytoplasmic expression or AQP1 low cytoplasmic expression (log-rank test). h Overview of the AQP1/ANXA2/Rab1b signaling pathway in breast cancer local invasion