Fig. 4
A Dynamic and homeostatic control of neutrophils. Legend: Neu: neutrophil. Without any immune stimulation, the neutrophil level in the blood is controlled by a balance between input from bone marrow and cell survival, which is regulated by cytokines, such as G-CSF, IL-23, and IL-17. The homeostasis is disrupted by immune stimulation, as observed in inflammation. B Dynamic and homeostatic control of monocytes. Legend: Classic, Int, and non-classic: classical, intermediate, and non-classical monocytes, respectively. Without immune stimulation, monocyte levels in the blood result from a balance among inputs from the bone marrow, cell survival, and differentiation into long-lived monocytes. The homeostasis is disrupted by immune stimulation, as observed in inflammation