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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Targeting IGF1R signaling enhances the sensitivity of cisplatin by inhibiting proline and arginine metabolism in oesophageal squamous cell carcinoma under hypoxia

Fig. 7

IGF1R reduces the sensitivity of OSCC cells to DDP by targeting arginine and proline metabolism under hypoxia. A, D PCA score plots obtained from metabolite profiles of KYSE150 transfected with control and shASS1(A)/PYCR1(D). B, E Volcano map of the altered metabolites in group shASS1(B)/PYCR1(E) compared to group control. C, F Enriched metabolic pathways analysis of abnormal metabolites in group shASS1(C)/PYCR1(F) compared to group control. G, H Bubble diagram of enrichment analysis on abnormal metabolites in group shASS1(G)/PYCR1(H) compared to group control. I The relative arginine (Top) and proline (Bottom) levels in KYSE150 in different groups. J, K Proliferation ability in different groups treated with DDP under low oxygen conditions. L The relative NAD + levels in low oxygen conditions compared to normal conditions (left), and in groups shPYCR1 + DDP, shASS1 + DDP compared to groups control + DDP (right). Student’s t test. NS: not signifcant, *p < 0.05, **p < 0.01

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