Fig. 7From: Targeting IGF1R signaling enhances the sensitivity of cisplatin by inhibiting proline and arginine metabolism in oesophageal squamous cell carcinoma under hypoxiaIGF1R reduces the sensitivity of OSCC cells to DDP by targeting arginine and proline metabolism under hypoxia. A, D PCA score plots obtained from metabolite profiles of KYSE150 transfected with control and shASS1(A)/PYCR1(D). B, E Volcano map of the altered metabolites in group shASS1(B)/PYCR1(E) compared to group control. C, F Enriched metabolic pathways analysis of abnormal metabolites in group shASS1(C)/PYCR1(F) compared to group control. G, H Bubble diagram of enrichment analysis on abnormal metabolites in group shASS1(G)/PYCR1(H) compared to group control. I The relative arginine (Top) and proline (Bottom) levels in KYSE150 in different groups. J, K Proliferation ability in different groups treated with DDP under low oxygen conditions. L The relative NAD + levels in low oxygen conditions compared to normal conditions (left), and in groups shPYCR1 + DDP, shASS1 + DDP compared to groups control + DDP (right). Student’s t test. NS: not signifcant, *p < 0.05, **p < 0.01Back to article page