Fig. 9

The effects of circFOXK2 on HCC. Schematic diagram illustrating the potential molecular mechanisms through which circFOXK2 regulates the Warburg effect and subsequently promotes HCC progression by not only translating into a novel protein, circFOXK2-142aa, to interact with LDHA and regulate its phosphorylation but also functions as a ceRNA to sponge miR484 and subsequently regulate Fis1 expression as well as induces mitochondrial fission