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Fig. 10 | Journal of Experimental & Clinical Cancer Research

Fig. 10

From: Guadecitabine increases response to combined anti-CTLA-4 and anti-PD-1 treatment in mouse melanoma in vivo by controlling T-cells, myeloid derived suppressor and NK cells

Fig. 10

Guadecitabine/ICBs reduce TAM-M2 percentages among total macrophages. mIF analysis of lung tumor tissue slides (n=3-6 mice/group). Histograms show, starting from left side, the frequency of CD206+ among total macrophages, percent of CD206+ cells in 30µm proximity to CD8+ cells, the frequency of CD8+ cells within 30µm distance to macrophages CD206- and the frequency of CD206+ cells within 30µm distance to MDSC in the lung from mice receiving different treatments. *p<0.05, **p<0.02, ***p<0.01, ****p<0.001

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