Fig. 14

Significant biological networks generated by differentially methylated probes filtered in terms of MAD based on the connectivity of the genes including the methylation probes. The network is constituted by genes involved in the lymphoid tissue structure and development and in the homeostasis of the immune system. All genes identified are hypomethylated by Guad treatment and are predicted to activate several processes of the immune system represented by trapezoidal shapes. Green genes represent demethylated genes, blue hexagonal shapes represent biological processes predicted to be activated by demethylated genes and orange hexagonal shapes those predicted to be inactivated