Fig. 1

FBXW7β is the main form in ESCC cells and is almost mutated in the WD40 domain. Schematic diagram of the structure of different FBXW7 isoforms. A mRNA levels of different FBXW7 isoforms in ESCC cells. B Immunofluorescence of FBXW7 in ESCC cells. C The results of FBXW7 mutation site using Sanger sequencing in ESCC tissues. D Schematic diagram of the location of mutation sites in the FBXW7 WD40 domain. E Schematic diagram of the location of mutation sites in the FBXW7 WD40 domain