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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: TERRA G-quadruplex stabilization as a new therapeutic strategy for multiple myeloma

Fig. 1

Hit 17 inhibits MM cell viability and activates apoptotic signaling. A RT-qPCR of TERRA in MM patients and HD. B Four MM cell lines and (C) PBMCs from 10 healthy donors were treated with hit 17 at indicated concentrations for 48 h, followed by Cell Titer-Glo assay. NCI-H929 (D) and AMO-1 (E) cells were treated with hit 17 (1, 2.5, and 5 μM) for 48 h. Cells were then stained with Annexin V-PE and 7-AAD, followed by flow cytometry analysis. The number of each quadrant was presented in %. F WB analysis of cleaved caspase-3 and cleaved PARP1 in the NCI-H929 cell line. Results shown in B, D-F are the average of three independent biological replicates. Error bars are SD

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