Fig. 4
From: Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
The mechanism of tumor-serected exosomal cargos induce angiogenesis through metabolic reprogramming. TEXs can be delivered to various types of cells to induce angiogenesis. AML cells-derived exosomal VEGF and VEGFR mRNA can enhance ECs glycolysis and induce angiogenesis. HNSCC cells-derived exosomal CD39, CD73 and metabolite ADO can induce A2BR-mediated M2-polarized TAMs and promote their secretion of angiogenic factors to induce angiogenesis. Exosomal CD39, CD73 and ADO can also directly promote ECs growth. EPC-derived exosomal miR-210 maintains vascular stability by adjusting ROS and ATP levels