Fig. 6
From: Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
The mechanism of tumor-serected exosomal cargos regulate metabolic reprogramming of stromal cells. In addition to CAFs, adipocytes and stellate cells are the stromal cell components in TME. Pancreatic cancer-derived exosomes can reduce TG production by promoting IL-6 expression and lipolysis. AM in pancreatic cancer exosomes can activate the p38/ERK1/2 signaling axis, promote intracellular lipolysis, and increase extracellular free fatty acids. Breast cancer-secreted exosomal miR-155 can target PPARγ to promote CAAs beige/brown differentiation. Breast cancer-secreted exosomal miR-126 can inhibit the IRS/Glut-4 axis to reduce CAAs lipid droplet accumulation and glucose uptake, and exosomal miR-144 can inhibit the MAP3K8/ERK1/2/PPARγ axis to promote CAAs beige/brown differentiation. Pancreatic cancer-secreted exosomal IL-17B can activate PSCs by promotingIL-17RB expression and enhancing OXPHOS. CRC-secreted exosomal HSPC111 can activate HSCs by regulating acetyl-CoA expression, ACLY phosphorylation, and increase citrate content