Fig. 7
From: Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
The mechanism of CAFs-derived exosomal cargos regulate metabolic reprogramming of tumor cells. CAFs regulate metabolic reprogramming of tumor cells mainly by exosomal nucleic acids. Exosomal miR-522 activates the USP7/hnRNPA1 pathway by targeting ALOX15, blocking the accumulation of lipid-ROS. Exosomal SNHG3 inhibits OXPHOS and promotes glycolysis through the miR-330-5p/PKM axis. Exosomal TUG1 promotes glycolysis through the miR-524-5p/SIX1 axis. Exosomal LINC01614 enhances tumor cells glutamine uptake by up-regulating glutamine transporters SLC38A2 and SLC7A5. In addition, exosomal mtDNA can lead to endocrine therapy resistance in OXPHOS-dependent breast cancer