Fig. 8
From: Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
The mechanism of TAMs-derived exosomal cargos regulate metabolic reprogramming of tumor cells. TAMs-derived exosomal cargos mainly affect tumor cells glycolysis and OXPHOS. Exosomal HISLA promotes glycolysis by inhibiting the binding of HIF-1α to its hydroxylase PHD2. Exosomal miR-222-3p promotes glycolysis by targeting PDLIM2 to inhibit the ubiquitinated degradation of PFKL. Exosomal miR-503-3p activates the Wnt/β-catenin signaling pathway by targeting DACT2 to promote glycolysis and inhibit OXPHOS