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Fig. 9 | Journal of Experimental & Clinical Cancer Research

Fig. 9

From: Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment

Fig. 9

The mechanism of adipocytes-derived exosomal cargos regulate metabolic reprogramming of tumor cells. The effect of adipocytes-derived exosomal cargos on tumor cells metabolism is reflected in lipid. Some FAO-associated proteins are enriched in adipocytes-derived exosomes and promote FAO in tumor cells via exosomes. Exosomal miR-433-3p targets SCD1 to promote lipid accumulation in tumor cells. Exosomal miR-23a/b targets VHL to promote HIF-1α expression, which enhances GLUT-1 expression and 5-FU resistance in tumor cells

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