Table 4 Therapeutics targeting exosome-mediated metabolism
From: Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
Drug/Method | Tumor | Therapeutic target | Therapeutic effect | Reference |
|---|---|---|---|---|
Shikomin | NSCLC | Exosomal PKM2↓ | Cisplatin sensitivity↑ | [290] |
Shikomin | Bladder cancer | Exosome release↓ | Cisplatin sensitivity↑ | [291] |
Exosome-transported si-ciRS-122 | CRC | Glycolysis↓ | Oxaliplatin sensitivity↑ | [292] |
Coptisine | HCC | Exosomal circCCT3↓ | Proliferation, invasion↓ | [293] |
DHA | BC | Exosomal miR-101, miR-9, miR-342↑ miR-382, miR-21↓ | Angiogenesis↓ | [294] |
Exosome-mediated cPLA2 siRNA | GBM | Energy metabolism↓ | Proliferation↓ | [295] |
TEX-mediated AIEgens and PPI | GC | Glutamine metabolism↓ | PDT↑ | [296] |