Fig. 6
From: METTL3 promotes chemoresistance in small cell lung cancer by inducing mitophagy
DCP2 regulates mitophagy mediated by the Pink1-Parkin pathway. A-B qRT–PCR analysis of the mRNA expression of mitophagy-related proteins after knockdown of DCP2 in the drug-sensitive cell lines H69 and H446. **P < 0.01; ***P < 0.001; ns, not significant. C qRT–PCR analysis of the mRNA expression of mitophagy-related proteins after overexpression of DCP2 in the drug-resistant cell lines H69AR and H446DDP. **P < 0.01. D-E Western blot analysis of mitophagy-related protein expression after knockdown of DCP2 (D) and overexpression of METTL3 (E) in the drug-sensitive cell lines H69 and H446. F-G Western blot analysis of mitophagy-related protein expression after knockdown of METTL3 (F) and overexpression of DCP2 (G) in the drug-resistant cell lines H69AR and H446DDP. H Western blot analysis of mitophagy-related protein expression after simultaneous METTL3 and DCP2 knockdown in the drug-resistant cell lines H69AR and H446DDP