Fig. 7

DCP2 regulates mitochondrial damage levels in SCLC cells. A-B The mitochondrial membrane potential detection kit (JC-1) was used to detect differences in mitochondrial damage levels in DCP2 knockdown SCLC cells following treatment with the chemotherapeutic drugs CDDP and VP16 (when the mitochondrial membrane potential is high, JC-1 aggregates in the mitochondrial matrix to form polymers and produces red fluorescence; when the mitochondrial membrane potential is low, JC-1 exists in monomer form and cannot aggregate in the mitochondria in the matrix, which produces green fluorescence). C-D A mitochondrial membrane potential detection kit (JC-1) was used to detect differences in mitochondrial damage levels in DCP2-overexpressing SCLC cells following treatment with chemotherapeutic drugs. E-F A mitochondrial membrane potential detection kit (JC-1) was used to detect differences in mitochondrial damage levels in SCLC cells with simultaneous knockdown of METTL3 and DCP2 following treatment with chemotherapeutic drugs